Anthelmintic effect of Pterogyne nitens (Fabaceae) on eggs and larvae of Haemonchus contortus: Analyses of structure-activity relationships based on phenolic compounds

Due to high prevalence and large pathogenicity, Haemonchus contortus is the main gastrointestinal nematode in tropical subtropical regions. This species responsible for severe economic losses sheep goat breeders Brazil. The control of this parasite currently compromised, mainly, due anthelmintic resistance. In search natural alternatives, Pterogyne nitens, a native Brazilian tree with potential ethnopharmacological activity, has been identified. aim study was evaluate activity ethanolic extracts phenolic compounds from P. as well two commercial flavonoids (chrysin morin), derive chemical structure activity. ovicidal larvicidal leaves (EEL) fruits (EEFR), nitens on H. were evaluated through egg hatch assay (EHA) larval development (LDA). results showed that all extracts, especially active EHA LDA. inhibitory effects EEL (EC50 = 316 ?g/mL) more potent than EEFR 512 ?g/mL). However, 47 35 similar. Among compounds, flavones (sorbifolin, pedalitin, chrysin) did not have hatching but presented some against contortus. contrast, flavonols (quercetin, rutin, morin) inactive addition at hydroxyl group rutinose flavonoid increased respectively. acids activity: caffeic acid, ferulic gallic acid had highest effects, presenting EC50 values 1.48, 0.56, 4.93 ?g/mL EHA; 31, 22, 33 LDA, These suggest might be source effective alternative